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There's been no previous information around the result of hypoxia to the differentiation of SMCs from ASCs. Our review is the initial study to point out that a 5% oxygen concentration Increased the differentiation of ASCs to form contractile SMCs and confirmed that purposeful SMCs could possibly be made from ASCs in vitro with a mix of TGF-β1 and BMP4.
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The impact of hypoxia on contractility of SMCs and ASCs. (A) Collagen gel lattices made up of undifferentiated or differentiated SMCs and ASCs have been cultured for 24 h and photographed for the indicated time details right after induction with carbachol.
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